• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Hybrid breakdown caused by substitution of the X chromosome between two mouse subspecies.
【2h】

Hybrid breakdown caused by substitution of the X chromosome between two mouse subspecies.

机译：由两个小鼠亚种之间的X染色体替换引起的杂种分解。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hybrid breakdown is a type of reproductive failure that appears after the F2 generation of crosses between different species or subspecies. It is caused by incompatibility between interacting genes. Genetic analysis of hybrid breakdown, particularly in higher animals, has been hampered by its complex nature (i.e., it involves more than two genes, and the phenotype is recessive). We studied hybrid breakdown using a new consomic strain, C57BL/6J-X(MSM), in which the X chromosome of C57BL/6J (derived mostly from Mus musculus domesticus) is substituted by the X chromosome of the MSM/Ms strain (M. m. molossinus). Males of this consomic strain are sterile, whereas F1 hybrids between C57BL/6J and MSM/Ms are completely fertile. The C57BL/6J-X(MSM) males showed reduced testis weight with variable defects in spermatogenesis and abnormal sperm head morphology. We conducted quantitative trait locus (QTL) analysis for these traits to map the X-linked genetic factors responsible for the sterility. This analysis successfully detected at least three distinct loci for the sperm head morphology and one for the testis weight. This study revealed that incompatibility of interactions of X-linked gene(s) with autosomal and/or Y-linked gene(s) causes the hybrid breakdown between the genetically distant C57BL/6J and MSM/Ms strains.
机译：杂种分解是繁殖失败的一种类型，出现在不同物种或亚种之间杂交的F2代之后。这是由于相互作用基因之间的不相容性引起的。杂种分解的遗传分析，特别是在高等动物中，由于其复杂的性质而受到阻碍（即，它涉及两个以上的基因，并且表型是隐性的）。我们研究了使用新的纯系C57BL / 6J-X（MSM）的杂种分解，其中C57BL / 6J的X染色体（主要来源于家蝇）被MSM / Ms菌株（M m。molossinus）。该纯系的雄性是不育的，而C57BL / 6J和MSM / Ms之间的F1杂种完全可育。 C57BL / 6J-X（MSM）雄性小鼠睾丸重量减少，精子发生异常和精子头部形态异常。我们对这些性状进行了数量性状基因座（QTL）分析，以绘制造成不育的X连锁遗传因素。这项分析成功地检测出至少三个不同的精子头形态位点和一个睾丸重量。这项研究表明，X连锁基因与常染色体和/或Y连锁基因之间的相互作用不兼容会导致遗传距离较远的C57BL / 6J与MSM / Ms菌株之间发生杂交。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号